Histological changes in liver associated with administration of hydroxyurea inmale albino mice

Abstract EN

Hydroxyurea (HU) have been used for treatment of a variety of tumors.

It becomes standard therapy for chronic myelogenous leukemia, polycythemia and sickle cell disease.

Numerous studies have been published about their side effects but less studies has dealt with HU effect in histological structure of liver, therefore these experiments were designed to study the effect of HU on hepatic tissue.

We concluded that HU had negative side effect in the liver.