Salivary acid and alkaline ribonuclease in the different types of tumors

Abstract EN

Novel study has been carried on acid and alkaline RNase activities in saliva using yeast RNA as a substrate in normal healthy male and female control (n = 22) and different types of tumors patients such as Multiple Myeloma (n = 20), Non-Hodgkin's Lymphoma (n = 18), Brest Cancer (n = 20) and Leukemia (n =16).

There was a significant difference in salivary alkaline RNase activity between control and the different tumors (p<0.001).

A statistically difference in salivary acid RNase activity was also found between control and Multiple Myeloma, Breast Cancer (p<0.001).The protein concentration shows large decrease in the all different tumors.

These results suggest that the high RNase levels of tumors are due to an excessive leakage of alkaline RNase into the blood stream from abnormal disorder and transport to the saliva.