Immunology of staphylococcal human persistent pyuria

Abstract EN

Fifteen Staphylococcus aureus isolates from human with persistent pyuria were diagnosed .Patient had high total serum protein (7.178 g/dl), high serum (4.081 g/dl) and mucosal globulins concentration (0.072g / dl] and lowered serum albumin globulin ratio (56.68%) in comparison to normal subjects.

These patients were with significant anti S.

aureus specific agglutinins both at serum and mucosal Secretions.

Their peripheral and mucosal leucocyte migration inhibition (LIF) were significant (peripheral 0.5, mucosal 0.58) .Non significant anti S.

aureus agglutinins and LIF were noted in blood and secretion of five immunecompromized, these five cases were showing low grade (specific antibody titre 40, LIF, peripheral 0.8, mucosal 0.75) immune responses due an immunocompromy.

The involved immunodominant epitopes in these immune responses may be T dependent types that can activate either or both Th1, Th2.

For humeral arm direct B cell epitope maybe expected also.