Allograft renal rejection and chemokine polymorphism
Joint Authors
Gorgi, Y.
Safar, I.
Jandubi-Ayid, S.
Bin Rhomdhane, T.
Aouadi, H.
Abd al-Rahim, E.
Ayid, K.
Makhluf, M.
Bardi, R.
Bin Abd Allah, Tayyib
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 22, Issue 1 (28 Feb. 2011), pp.18-23, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2011-02-28
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Chemokines play a major role in the process by which leukocytes are recruited from the bloodstream into the sites of inflammation.
Genes for the chemokine receptors CCR5, CCR2 and MCP-1 are characterized by functional polymorphisms implicated in transplant rejection.
To investigate this association, we analyzed polymorphisms of CCR5-∆32, CCR5-59029-A/G, CCR2-V64I and MCP-1 G/A (-2518) in 173 renal transplant recipients and 169 healthy blood donors.
The patients were classified in two groups: Group-1 (G-1) included 33 HLA-identical recipients and Group-2 (G-2) included 140 (one or more) mismatched graft recipients.
Forty-two patients had developed acute rejection episodes (ARs): seven in G-1 and 35 in G-2.
Thirteen G-2 patients developed chronic allograft dysfunction (CAD).
The genotypic and allelic frequencies of all polymorphisms studied did not reveal significant differences between patients and controls and among G-1 and G-2 recipients.
However, a significant risk of acute renal transplant rejection was found in G-1 patients who possessed the CCR2-64I allele (odds ratio 0.24, 95% confidence interval [CI], 0.05-1.06; P = 0.035).
There was no significant association of this polymorphism and CAD.
In conclusion, the observed association of CCR2-64I with AR should be added to the spectrum of immunogenetic factors known to be involved in allograft renal loss.
American Psychological Association (APA)
Gorgi, Y.& Safar, I.& Jandubi-Ayid, S.& Makhluf, M.& Bin Rhomdhane, T.& Bardi, R.…[et al.]. 2011. Allograft renal rejection and chemokine polymorphism. Saudi Journal of Kidney Diseases and Transplantation،Vol. 22, no. 1, pp.18-23.
https://search.emarefa.net/detail/BIM-245096
Modern Language Association (MLA)
Gorgi, Y.…[et al.]. Allograft renal rejection and chemokine polymorphism. Saudi Journal of Kidney Diseases and Transplantation Vol. 22, no. 1 (Feb. 2011), pp.18-23.
https://search.emarefa.net/detail/BIM-245096
American Medical Association (AMA)
Gorgi, Y.& Safar, I.& Jandubi-Ayid, S.& Makhluf, M.& Bin Rhomdhane, T.& Bardi, R.…[et al.]. Allograft renal rejection and chemokine polymorphism. Saudi Journal of Kidney Diseases and Transplantation. 2011. Vol. 22, no. 1, pp.18-23.
https://search.emarefa.net/detail/BIM-245096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references.
Record ID
BIM-245096