Relations between serum essential fatty acids cytokines (il-6 & il- 8), apoptotic marker (SFAS), and free radicals in Egyptian patients with autoimmune diseases
Joint Authors
Ghanim, Halah M.
Abduh, Samiyah A.
Source
The Egyptian Journal of Biochemistry and Molecular Biology
Issue
Vol. 27, Issue 2 (31 Dec. 2009), pp.29-44, 16 p.
Publisher
Egyptian Society of Biochemistry and Molecular Biology
Publication Date
2009-12-31
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Topics
Abstract EN
Eicosanoids, lymphocytes, free radicals and apoptotic marker are known to participate in the pathogenesis of inflammation.
The aim of this study was to investigate the relations between free radical generation, interleukins (IL-6 & IL-8), apoptotic marker soluble Fas (sFa.s), and the level of essential fatty acids and their metabolites in patients with autoimmune diseases.
The study was conducted on 37 patients admitted to Rheumatology Unit Hospital of Ain Shams University ; in addition there were 10 control subjects.
The patients suffered from different types of autoimmune diseases according to their criteria, Rheumatoid arthritis (RA), and systemic lupus erythematous (SLE), systemic sclerosis (SSC) and overlap syndrome.
Serum levels of total glutathione (reduced; GSH and oxidized; GSSG) were estimated by HPLC; serum MDA, IL-6, IL-8 and sFas were also assayed.
In addition serum fatty acids were determined by using GLC.
The inflammations resulting from the studied autoimmune diseases induced significant decrease in serum level of GSH, and marked increase in the levels of GSSG, MDA, IL-6, IL-8 and sFas whereas serum fatty acid revealed that Linoleic acid (LA) and alpha linoleic acid (ALA) were significantly decreased in the studied cases.
LA metabolite (arochidonic acid; AA) is markedly increased while ALA metabolite (eieosapentaenoic ; EPA) & docosahexaenoic (DHA) were significantly increased.
These results suggest that essential! Fatty acid metabolism is altered in autoimmune diseases.
The interactions between essential fatty acids, eicosanoids, lymphoid ties and free radicals suggest that new therapeutic strategies can be devised to modify the course of these diseases.
American Psychological Association (APA)
Ghanim, Halah M.& Abduh, Samiyah A.. 2009. Relations between serum essential fatty acids cytokines (il-6 & il- 8), apoptotic marker (SFAS), and free radicals in Egyptian patients with autoimmune diseases. The Egyptian Journal of Biochemistry and Molecular Biology،Vol. 27, no. 2, pp.29-44.
https://search.emarefa.net/detail/BIM-246198
Modern Language Association (MLA)
Ghanim, Halah M.& Abduh, Samiyah A.. Relations between serum essential fatty acids cytokines (il-6 & il- 8), apoptotic marker (SFAS), and free radicals in Egyptian patients with autoimmune diseases. The Egyptian Journal of Biochemistry and Molecular Biology Vol. 27, no. 2 (Dec. 2009), pp.29-44.
https://search.emarefa.net/detail/BIM-246198
American Medical Association (AMA)
Ghanim, Halah M.& Abduh, Samiyah A.. Relations between serum essential fatty acids cytokines (il-6 & il- 8), apoptotic marker (SFAS), and free radicals in Egyptian patients with autoimmune diseases. The Egyptian Journal of Biochemistry and Molecular Biology. 2009. Vol. 27, no. 2, pp.29-44.
https://search.emarefa.net/detail/BIM-246198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 40-44
Record ID
BIM-246198