Synthesis and biological evaluation of a novel series of 2-(4-chloro-3-methylphenoxy)‎acetyl amino acids and peptides

Abstract EN

A series of new 2-(4-chloro-3-methylphenoxy) acetyl amino acids and peptides have been synthesized by coupling the 2-(4-chloro-3-methylphenoxy) acetic acid with amino acid methyl esters / peptides using DCC as coupling agent and NMM as base.

The structures were elucidated by elemental analysis, IR, 1H NMR, 13 C NMR and MS spectral data.

The newly synthesized compounds were also evaluated for antibacterial and antifungal activities.

Compounds 3, 4 and 6 were found to exhibit potent antibacterial activity against gram negative bacteria Pseudomonas aeruginosa, gram positive bacteria Staphylococcus aureus and compounds 8, 10 and 11 were found to be potent antifungal agents against pathogenic Candida albicans.