Cadmium chloride toxicity and the possible role of vitamin A

Abstract EN

This study was carried out on thirty adult male albino rats.

The rats were divided into three equal groups the 1st group fed ordinary rat diet was used as control, the second group was administered cadmium chloride (Cdcl2) at a dose of 8 mg/kg b.wt., orally daily for 8 weeks, the 3rd group were given vitamin A 250 IU/kg b.w., daily orally for 7 days prior to cadmium and for another 8 weeks during cadmium chloride (Cdcl2) administration.

The following biochemical parameters were done; renal profile (serum creatinine, blood urea), hepatic profile (SGOT, SGPT, ALP and TSB), serum sodium, potassium , calcium, testosterone, serum and tissue cadmium level.

The biochemical results showed highly significant increase in serum renal, hepatic profiles, sodium, calcium and significant decrease in serum potassium and serum testosterone after Cdcl2 ingestion.

Regarding serum and tissue Cdcl2 level, there is a significant increase of both levels in kidney and liver in contrast there was no alteration in testicular cadmium.

The prior and co-administration of vitamin A before cadmium administration succeeded to restore liver , kidney functions and serum testosterone to their normal level.