![](/images/graphics-bg.png)
lnterleukin-8 as a marker of sepsis and its relation to organ SUfunction and patient outcome in the pediatric intensive care
Joint Authors
al-Nadi, Ghadah
Abd al-Qadir, Ala Muhammad
Source
Egyptian Pediatric Association Gazette
Issue
Vol. 57, Issue 1 (13 Jan. 2009), pp.39-46, 8 p.
Publisher
Egyptian Pediatric Association
Publication Date
2009-01-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background: the diagnosis of sepsis remains elusive and there is a need for biomarkers to help recognition of those critically ill patients, lnterleukin-8 (IL-8) plays an important role in the pathogenesis of sepsis, and is often highly elevated in septic patients. Aims : to evaluate the accuracy of IL-8 serum levels to discriminate patients with sepsis from those with systemic inflammatory response syndrome (SIRS) among critically ill pediatric patients.
Relation of IL-8 serum levels to severity of sepsis and patients' outcome was also assessed. Methods : we conducted a prospective observational study on 64 critically ill patient classified as: SIRS (group A; n = 17), sepsis (group B; n = 28), and severe sepsis (group C; n = 19).
IL-8 was measured on pediatric intensive care unit (PICU) admission (TO) and then after 24 hours (Tl) of admission. Results : in this work, admission (TO) and 24 hour (Tl) plasma levels of IL-8 were significantly increased in septic patients (groups B and C) compared to SIRS patients (group A).
The area under the receiver operating characteristic curve for prediction of sepsis from SIRS was 0.870 for IL-8 (TO); a cut-off value of 198.34 pg / ml had 78.3% sensitivity, and 81.2% specificity.
IL-8 levels (TO) and (Tl) were significantly increased in non-survivors, and increase in serum IL-8 (Tl) level following admission may be associated with mortality.
Admission levels of IL-8 were significantly increased in group A and B patients who went to develop the two or more organ failure within the first 48 hours of PICU admission.
Conclusion: Admission levels of IL-8 could be used to discriminate septic patients and correlate with disease severity; highest levels of IL-8 were associated with development of organ failure and mortality in the PICU.
American Psychological Association (APA)
Abd al-Qadir, Ala Muhammad& al-Nadi, Ghadah. 2009. lnterleukin-8 as a marker of sepsis and its relation to organ SUfunction and patient outcome in the pediatric intensive care. Egyptian Pediatric Association Gazette،Vol. 57, no. 1, pp.39-46.
https://search.emarefa.net/detail/BIM-249205
Modern Language Association (MLA)
Abd al-Qadir, Ala Muhammad& al-Nadi, Ghadah. lnterleukin-8 as a marker of sepsis and its relation to organ SUfunction and patient outcome in the pediatric intensive care. Egyptian Pediatric Association Gazette Vol. 57, no. 1 (Jan. 2009), pp.39-46.
https://search.emarefa.net/detail/BIM-249205
American Medical Association (AMA)
Abd al-Qadir, Ala Muhammad& al-Nadi, Ghadah. lnterleukin-8 as a marker of sepsis and its relation to organ SUfunction and patient outcome in the pediatric intensive care. Egyptian Pediatric Association Gazette. 2009. Vol. 57, no. 1, pp.39-46.
https://search.emarefa.net/detail/BIM-249205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 45-46
Record ID
BIM-249205