Evaluation of osseous response to bioglassdextrin composite in induced mandible defects : an experimental study

Abstract EN

Objectives : this experimental study was made to evaluate the osteopenia potential of Bio glass / Dextran composite clinically, radio graphically and histologically in induced mandibular bone defects in 12 mongrel dogs and suitability of this material to the ridge augmentation procedures.

Materials and Methods : in the right mandibular side, first molar was removed followed by localized alveolectomy then the site was compressed with the composite graft while in the left side, a rectangular defect was surgically induced with dimensions 20 x 10 x 5 mm just below the inferior alveolar canal then compressed with the graft material.

Both grafted defects were compared with the control animals along intervals 3, 6 and 12 weeks postoperative periods clinically, radio graphically, histologically and histomorphometrically.

Results : the current study proved that this composite is bioactive, has high osteopenia potential and could be used effectively in large osseous defects without any adverse inflammatory, allergic or cytotoxic reactions.

In addition, this composite could be used in alveolar ridge augmentation procedures as it caused a statistically significant increase in rate and density of bone formation in these defects compared to the control animals.

Conclusion : bio glass / Dextran composite is an effective osteoconductive and osteostimulatory graft material that could be used in large osseous defects and in ridge augmentation procedures especially with the use of barrier membrane.