Effect of open reduction and internal fixation (ORIF)‎ on salivary immunoglobulin a (SIGA)‎ in parasymphyseal fractures of mandible

Abstract EN

Objectives : oral and maxillofacial trauma studied has been directed extensively towards improvement of surgical approaches, appliances, and techniques, yet the study of surgical trauma with regards patient's immunocompetence has not received the same attention.

The present investigation was directed to clarify the effect of open reduction and internal fixation (ORIF) and surgical insult in cases of parasymphyseal mandibular fractures on salivary immunoglobulin A (SIgA).

It was hoped to rationalize the trauma associated with surgery, especially in cases of already traumatized patients.

This was an attempt to give the oral mucosal immune system the due attention in planning of different surgical techniques.

Patients and Methods : Fourteen adult Egyptian patients with parasymphyseal mandibular fractures were the subjects of this study.

All patients have been treated under general an aesthesia (G.A.).

Patients were divided randomly into two equal groups ; Group I : parasymphyseal fractures were managed by non-surgical lingual splint.

Group II : parasymphyseal fractures were managed by surgical open reduction and internal fixation (ORIF).

Unstipulated whole saliva samples were collected from the patients preoperatively (on the day of admission), postoperatively (before discharge), 24 hours postoperatively, then at one week, three weeks, six weeks, and eight weeks postoperatively.

The quantitative determination of the concentration of salivary immunoglobulin A (SIgA) was done by enzyme linked immunosorbent assay (ELISA).

The data was tabulated and statistically analyzed.