QSAR based modeling of hepatitis C virus NS5B inhibitors
Joint Authors
Srivastava, A. K.
Srivastava, Akanchha
Shukla, Neerja
Pandey, Avni
Source
Journal of Saudi Chemical Society
Issue
Vol. 15, Issue 1 (31 Jan. 2011), pp.25-28, 4 p.
Publisher
Publication Date
2011-01-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
QSAR analysis on a series of 13 derivatives of 5-hydroxy-3-(2H)-pyridazinone as hepatitis C virus NS5B polymerase inhibitors was performed.
The inhibitory activities of these compounds were found to increase with density (D), index of refractivity (lor), surface tension (St), electro negativity (Xeq) and decrease with the balaben centric index (Bac), balaben distance connectivity index (J) and zero order connectivity (X°) along with the indicator parameter.
Excellent results were obtained from regression upon introduction of the indicator parameter.
The results are critically discussed on the basis of regression data and cross validation technique.
American Psychological Association (APA)
Srivastava, A. K.& Pandey, Avni& Srivastava, Akanchha& Shukla, Neerja. 2011. QSAR based modeling of hepatitis C virus NS5B inhibitors. Journal of Saudi Chemical Society،Vol. 15, no. 1, pp.25-28.
https://search.emarefa.net/detail/BIM-250053
Modern Language Association (MLA)
Srivastava, A. K.…[et al.]. QSAR based modeling of hepatitis C virus NS5B inhibitors. Journal of Saudi Chemical Society Vol. 15, no. 1 (Jan. 2011), pp.25-28.
https://search.emarefa.net/detail/BIM-250053
American Medical Association (AMA)
Srivastava, A. K.& Pandey, Avni& Srivastava, Akanchha& Shukla, Neerja. QSAR based modeling of hepatitis C virus NS5B inhibitors. Journal of Saudi Chemical Society. 2011. Vol. 15, no. 1, pp.25-28.
https://search.emarefa.net/detail/BIM-250053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references: p. 28
Record ID
BIM-250053
