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Synthesis and reactions of some novel 4-biphenyl-4-(2)-phthalazin-l-one derivatives with an expected antimicrobial activity
Joint Authors
Abu Bshait, Haya Abd al-Wahhab
Abu Bshait, Samar A.
Kassab, Rafiqah R.
al-Shehri, Aisha H.
Source
Journal of Saudi Chemical Society
Issue
Vol. 15, Issue 1 (31 Jan. 2011), pp.59-65, 7 p.
Publisher
Publication Date
2011-01-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
In this study reaction of l-(biphenyl-4-carbonyl)benzoic acid (1) with hydrazine hydrate, phenyl hydrazine, acetyl hydrazine and benzoyl hydrazine in boiling dry benzene gave the corresponding 4-biphenyl-4-yl-(2H)-phthaIazin-l-one (2a-d), respectively.
The structure of 2c was established via its reaction with 2-chlorobenzaldehyde, 2-nitrobenzaldehyde in ethanol to give the chalcones 3a, b, respectively.
On the other hand, the cyclocondensation of the acid 1 with semicarb-azide and thiosemicarbazide in sodium acetate gave phthalazinone amide / thioamide 4a, b, respectively.
The reaction of 1 with hydroxyl amine hydrochloride in different media was also studied, to give the oxime derivative 5, which was readily converted to benzooxazin-1-one derivative 6 by boiling in acetic anhydride.
Compound 6 was also obtained, when the acid 1 was reacted with hydroxyl amine hydrochloride in boiling pyridine.
In addition, the phthalazinone derivative 2a reacted under Mannich reaction condition with phthalimide, morph line, o-crezole and B-naphthol
American Psychological Association (APA)
Abu Bshait, Samar A.& Kassab, Rafiqah R.& al-Shehri, Aisha H.& Abu Bshait, Haya Abd al-Wahhab. 2011. Synthesis and reactions of some novel 4-biphenyl-4-(2)-phthalazin-l-one derivatives with an expected antimicrobial activity. Journal of Saudi Chemical Society،Vol. 15, no. 1, pp.59-65.
https://search.emarefa.net/detail/BIM-250149
Modern Language Association (MLA)
Abu Bshait, Samar A.…[et al.]. Synthesis and reactions of some novel 4-biphenyl-4-(2)-phthalazin-l-one derivatives with an expected antimicrobial activity. Journal of Saudi Chemical Society Vol. 15, no. 1 (Jan. 2011), pp.59-65.
https://search.emarefa.net/detail/BIM-250149
American Medical Association (AMA)
Abu Bshait, Samar A.& Kassab, Rafiqah R.& al-Shehri, Aisha H.& Abu Bshait, Haya Abd al-Wahhab. Synthesis and reactions of some novel 4-biphenyl-4-(2)-phthalazin-l-one derivatives with an expected antimicrobial activity. Journal of Saudi Chemical Society. 2011. Vol. 15, no. 1, pp.59-65.
https://search.emarefa.net/detail/BIM-250149
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 65
Record ID
BIM-250149