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Sensitive spectrophometric determination of benoxnate hydrochloride using different aldehydes through condensation
Joint Authors
al-Farhan, Badriyah S.
Khalil, Hawwa M.
Source
Journal of Saudi Chemical Society
Issue
Vol. 15, Issue 1 (31 Jan. 2011), pp.89-93, 5 p.
Publisher
Publication Date
2011-01-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
Simple and sensitive spectrophotometric methods have been developed for the quantitative determination of benoxinate HC1 in bulk and in pharmaceutical formulations.
The first method depends on condensation of primary aromatic amine group of benoxinate HC1 with 4-dimethylami-nobenzaldehyde (PDAB) in presence of glacial acetic acid and the orange red colour developed was measured at 453 nm.
The linearity range was found to be 20-120 µg ml-1.
The second is based on the reaction with 4-dimethylaminocinnamaldehyde (DMAC) in 50% sulphuric acid producing a colored product which absorbs maximally at 549 nm.
Beer's law is obeyed in the concentration range 5-50 µg ml-1 of benoxinate HC1.
The third method is based on the reaction of benoxinate HC1 with acetyl acetone and formaldehyde in presence of acetate buffer pH 5.8 (Hantzsch reaction) and the colour developed was measured at 358 nm.
The absorbance is proportional to benoxinate HC1 concentration in the range 2-20 µg ml-1.
The optimum experimental parameters for the reactions have been studied.
The validity of the described procedures was assessed.
Statistical analysis of the results has been carried out revealing high accuracy and good precision.
The suggested procedures could be used for the determination of benoxinate HC1 in ophthalmic solution.
The procedures were rapid, simple and suitable for quality control application.
American Psychological Association (APA)
al-Farhan, Badriyah S.& Khalil, Hawwa M.. 2011. Sensitive spectrophometric determination of benoxnate hydrochloride using different aldehydes through condensation. Journal of Saudi Chemical Society،Vol. 15, no. 1, pp.89-93.
https://search.emarefa.net/detail/BIM-250172
Modern Language Association (MLA)
al-Farhan, Badriyah S.& Khalil, Hawwa M.. Sensitive spectrophometric determination of benoxnate hydrochloride using different aldehydes through condensation. Journal of Saudi Chemical Society Vol. 15, no. 1 (Jan. 2011), pp.89-93.
https://search.emarefa.net/detail/BIM-250172
American Medical Association (AMA)
al-Farhan, Badriyah S.& Khalil, Hawwa M.. Sensitive spectrophometric determination of benoxnate hydrochloride using different aldehydes through condensation. Journal of Saudi Chemical Society. 2011. Vol. 15, no. 1, pp.89-93.
https://search.emarefa.net/detail/BIM-250172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 92-93
Record ID
BIM-250172