Synthesis, spectral and antifungal studies of some coordination compounds of cobalt (II)‎ and copper (II)‎ of a novel 18-membered octaaza [N8] tetra dentate macro cyclic legend

Abstract EN

The stereochemistry and coordination behavior of Co (II) and Cu(Il) complexes of a novel 18-membered quadridentate macro cyclic ligand (3, 4, 12,13-tetra phenyl-l, 2, 5, 6, 10, ll, 14,15-octaazacyclooctadecane-7, 9, 16,18-tetraone-2, 4, ll, 13-tetraene) have been investigated after their template synthesis.

The synthesized macro cycles have been characterized by means of various phys-icochemical techniques viz.

elemental analyses, magnetic, conductivity measurements, and spectral (1R, electronic, mass and EPR) techniques.

The structure of complexes has been determined with the help of spectroscopic as well as conductivity values and found to be six coordinated octahedral and tetragonal for Co(II) and Cu (II), respectively.

The ligand was coordinated to the metal ion via the malonylhydrazide moiety s imine nitrogen in a tetra dentate fashion.

Molar conductance measurements revealed that reported macro cyclic complexes were non-ionic in nature.

All the complexes have been screened for their in vitro antifungal activity against a number of fungi isolated from plants.

The compounds exhibit significant antifungal activity.