A convenient, rapid microwave assisted synthesis of some novel 3-[(4-chloro-3-methylphenoxy)‎methyl]-6-aryl-5,6-dihydro-[l,2,4]triazolo[3,4-#][l,3,4]thiadiazoles using acidic alumina

Abstract EN

A facile synthesis of 3-[(4-chloro-3-methylphenoxy) methyl]-6-aryl-5,6-dihydro-[l, 2, 4]-triazolo[3, 4-β][l, 3, 4] thiadiazoles 3a-n has been achieved by microwave promoted condensation of 3-mercapto-4-amino-5-[ (4-chloro-3-methylphenoxy) methyl]-4H-l, 2, 4-diazole 1 with various aromatic aldehydes 2a-n in presence of catalytic amount of p-TsOH (para-toluenesulphonic acid).

The structures of 3a-n are supported by IR and 'H and 13C NMR spectral data.