Synthesis, characterization and spectroscopic studies of pyrazinamide metal complexes
Joint Authors
Budhani, Priya
Iqbal, Sayyid Aftab
Bhattacharya, Suman Malik Mamta
Mitu, Liviu
Source
Journal of Saudi Chemical Society
Issue
Vol. 14, Issue 3 (30 Sep. 2010), pp.281-285, 5 p.
Publisher
Publication Date
2010-09-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
The present paper deals with the synthesis and characterization of Schiff base complexes of pyrazinamide an ant tubercular drug.
Metals selected for complications are copper, silver, gold, zinc, mercury, iron and cobalt.
The complexes have been suitably synthesized and isolated in pure powdered form.
Analytical data agrees with the compositions M (L), M'(L) 2 and M"(L)2-2H2O, respectively where M = Ag, M' = Cu, Au, Zn and Hg and M" = Fe and Co, ligand metal ratios were also confirmed by monovariation method and Job's method of continuous variation.
Molar conductance values suggest the non ionic nature of the complexes.
The tentative structure assigned to the complexes on the basis of stoichiometry and analytical data were further supported by spectral studies viz; IR, NMR, magnetic susceptibility and electronic spectra.
A preliminary attempt has also been made to compare the potencies of metal complexes with parent drug.
The Cu and Ag complexes are giving encouraging results.
Particle size studies further suggest that the drug molecule undergoes reduction in size on complications.
American Psychological Association (APA)
Budhani, Priya& Iqbal, Sayyid Aftab& Bhattacharya, Suman Malik Mamta& Mitu, Liviu. 2010. Synthesis, characterization and spectroscopic studies of pyrazinamide metal complexes. Journal of Saudi Chemical Society،Vol. 14, no. 3, pp.281-285.
https://search.emarefa.net/detail/BIM-250540
Modern Language Association (MLA)
Budhani, Priya…[et al.]. Synthesis, characterization and spectroscopic studies of pyrazinamide metal complexes. Journal of Saudi Chemical Society Vol. 14, no. 3 (Sep. 2010), pp.281-285.
https://search.emarefa.net/detail/BIM-250540
American Medical Association (AMA)
Budhani, Priya& Iqbal, Sayyid Aftab& Bhattacharya, Suman Malik Mamta& Mitu, Liviu. Synthesis, characterization and spectroscopic studies of pyrazinamide metal complexes. Journal of Saudi Chemical Society. 2010. Vol. 14, no. 3, pp.281-285.
https://search.emarefa.net/detail/BIM-250540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 285
Record ID
BIM-250540