Synthesis and characterization of some pyrimidine-quinoline clubbed molecules and their microbicidal efficacy

Abstract EN

The required chalcones la-h were prepared by reaction of aryl acetophenone with different aryl aldehydes, which in turn treated with guanidine nitrate, yielded 4-(substituted phenyl)-6-(substituted phenyl)-2-pyrimidinamines 2a-h.

Novel pyrimidine-quinoline clubbed molecules 3a-h have been prepared by reaction of 2a-h with 4-chloro-2, 6-dimethylquinoline.

All the compounds were characterized by elemental analysis and spectral studies.

The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.