Synthesis and the influence of intramolecular H-bonding in NMR spectra of novel analogs of dendrodoine : diaminothiazoloylbenzothiazoles
Joint Authors
Reji, T. F. Abbs Fin
Rajasekharan, Kallikat Narayanan
Source
Journal of Saudi Chemical Society
Issue
Vol. 13, Issue 3 (31 Dec. 2009), pp.311-315, 5 p.
Publisher
Publication Date
2009-12-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Abstract EN
2-4-Amino-2-arylaminothiazol-5-(oyl) benzothiazoles, as the novel analogs of the cytotoxic marine alkaloid dendrodoine, are synthesized and characterized by elemental analysis, IR, NMR and mass spectral data.
The thiourea derivatives provide four ring atoms for the thiazole ring construction and thus act as [C-N-C-S] synthons.
The remaining carbon of the thiazole is sourced from 2-(2-bromoacetyl) benzothiazoles.
This [4+1] heterocyclization reaction is adopted for the synthesis of novel benzothiazole derivatives.
The presence of two signals in the 'H NMR spectrum arising from the NH2 hydrogen's shows that the two hydrogen's are not exchanging rapidly on the chemical shift time scale and they are in two different chemical environments due to H-bonding.
American Psychological Association (APA)
Reji, T. F. Abbs Fin& Rajasekharan, Kallikat Narayanan. 2009. Synthesis and the influence of intramolecular H-bonding in NMR spectra of novel analogs of dendrodoine : diaminothiazoloylbenzothiazoles. Journal of Saudi Chemical Society،Vol. 13, no. 3, pp.311-315.
https://search.emarefa.net/detail/BIM-250867
Modern Language Association (MLA)
Reji, T. F. Abbs Fin& Rajasekharan, Kallikat Narayanan. Synthesis and the influence of intramolecular H-bonding in NMR spectra of novel analogs of dendrodoine : diaminothiazoloylbenzothiazoles. Journal of Saudi Chemical Society (Mar. 2009), pp.311-315.
https://search.emarefa.net/detail/BIM-250867
American Medical Association (AMA)
Reji, T. F. Abbs Fin& Rajasekharan, Kallikat Narayanan. Synthesis and the influence of intramolecular H-bonding in NMR spectra of novel analogs of dendrodoine : diaminothiazoloylbenzothiazoles. Journal of Saudi Chemical Society. 2009. Vol. 13, no. 3, pp.311-315.
https://search.emarefa.net/detail/BIM-250867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 315
Record ID
BIM-250867