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Antinociceptive, anti-inflammatory and acute toxicity effects of juglans regia l. leaves in mice
Joint Authors
Hosseinzadeh, H.
Zarei, H.
Taghiabadi, E.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 13, Issue 1 (31 Mar. 2011), pp.27-33, 7 p.
Publisher
Publication Date
2011-03-31
Country of Publication
United Arab Emirates
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background: Juglans regia leaves have been used in folk medicine to alleviate inflammatory diseases.
This study investigates the antinociceptive, anti-Inflammatory and acute toxicity effects of Juglans regia L.
leaves in mice. Methods: 351 Male and female albino mice were divided into negative (saline), positive (morphine or diclofenac) controls as well as test groups (n=6-8).
The acute (intraperitoneally) toxicity was evaluated for 2 days.
Antinociceptive activities were done using hot-plate and writhing tests.
Anti-inflammatory effects were studied using xylene induced ear edema and cotton pellet tests. Results: The LD50 values of J.
regia aqueous and ethanolic extrats were 5.5 and 3.3 g/kg, respectively.
The aqueous (2.87 and 1.64 g/kg) and ethanolic (2.044 and 1.17 g/kg) extracts showed antinociceptive activity in hotplate test.
The pretreatment of naloxone (2 mg/kg, s.c.) did not inhibit the extracts activities.
The extracts exhibited antinociceptive activity in writhing test, which were not blocked by naloxone.
In xylene test, both extracts showed anti-inflammatory activity in some doses.
The extracts showed anti-inflammatory activity against the chronic inflammation. Conclusion: J.
regia leaves demonstrated antinociceptive effect through non-opioid receptors and antiinflammatory effect against acute and chronic inflammation.
The extracts of J.
regia could be considered as a promising analgesic and anti-inflammatory agents against diseases such as rheumatoid arthritis.
American Psychological Association (APA)
Hosseinzadeh, H.& Zarei, H.& Taghiabadi, E.. 2011. Antinociceptive, anti-inflammatory and acute toxicity effects of juglans regia l. leaves in mice. Iranian Red Crescent Medical Journal،Vol. 13, no. 1, pp.27-33.
https://search.emarefa.net/detail/BIM-252001
Modern Language Association (MLA)
Hosseinzadeh, H.…[et al.]. Antinociceptive, anti-inflammatory and acute toxicity effects of juglans regia l. leaves in mice. Iranian Red Crescent Medical Journal Vol. 13, no. 1 (Jan. 2011), pp.27-33.
https://search.emarefa.net/detail/BIM-252001
American Medical Association (AMA)
Hosseinzadeh, H.& Zarei, H.& Taghiabadi, E.. Antinociceptive, anti-inflammatory and acute toxicity effects of juglans regia l. leaves in mice. Iranian Red Crescent Medical Journal. 2011. Vol. 13, no. 1, pp.27-33.
https://search.emarefa.net/detail/BIM-252001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 32-33.
Record ID
BIM-252001