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The prevalence and clinical significance of anticardiolipin antibody in acute myeloblastic leukemia
Joint Authors
Cohan, N.
Ayatollahi, M.
Tahmasebi, J.
Ramzi, Muhammad
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 12, Issue 5 (30 Sep. 2010), pp.564-567, 4 p.
Publisher
Publication Date
2010-09-30
Country of Publication
United Arab Emirates
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background : ant phospholipid antibodies, including lupus anticoagulants and anticardiolipin (aCL) antibodies are associated with a wide variety of disorders including malignancies.
The aim of this study was to investigate the prevalence and prognostic significance of aCL antibodies in Iranian patients with acute meroblastic leukemia (AML).
Methods : Forty-one patients with AML (27 men and 14 women, mean age 34.9 ± 16.7 years) were included in this study.
aCL IgG and aCL IgM antibodies were evaluated in patients before induction chemotherapy.
All patients were followed up for chemotherapy response.
Results : antibodies (IgG, IgM or both) were found in 26 of 41 patients (63.4%), of whom 19 (46.%) had a low titer, 6 (14.6%) a moderate titer and 1 (2.4%) a high antibody titer.
No correlation was found between complete remission and relapse and aCL antibodies positivity.
Conclusion : aCL antibody titers are slightly to moderately elevated in patients with hematologic malignancies, and these antibodies do not correlate with disease prognosis.
American Psychological Association (APA)
Ramzi, Muhammad& Ayatollahi, M.& Tahmasebi, J.& Cohan, N.. 2010. The prevalence and clinical significance of anticardiolipin antibody in acute myeloblastic leukemia. Iranian Red Crescent Medical Journal،Vol. 12, no. 5, pp.564-567.
https://search.emarefa.net/detail/BIM-252231
Modern Language Association (MLA)
Ramzi, Muhammad…[et al.]. The prevalence and clinical significance of anticardiolipin antibody in acute myeloblastic leukemia. Iranian Red Crescent Medical Journal Vol. 12, no. 5 (Sep. 2010), pp.564-567.
https://search.emarefa.net/detail/BIM-252231
American Medical Association (AMA)
Ramzi, Muhammad& Ayatollahi, M.& Tahmasebi, J.& Cohan, N.. The prevalence and clinical significance of anticardiolipin antibody in acute myeloblastic leukemia. Iranian Red Crescent Medical Journal. 2010. Vol. 12, no. 5, pp.564-567.
https://search.emarefa.net/detail/BIM-252231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 566-567
Record ID
BIM-252231