Evaluation of the efficacy of aspirin and low molecular weight heparin in patients with unexplained recurrent spontaneous abortions
Joint Authors
Zolghadri, J.
Pour, F. Ahmad
Momtahan, M.
Tavana, Z.
Foroughinia, L.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 12, Issue 5 (30 Sep. 2010), pp.548-552, 5 p.
Publisher
Publication Date
2010-09-30
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : the roles of inflammatory cytokines and local placental thrombosis in patients with unexplained recurrent spontaneous abortion (URSA) have been shown.
Since low molecular weight heparin (LMWH) and acetyl salicylic acid (ASA) have both anti-inflammatory and anti-coagulant effect, we evaluated their efficacy in patients with URSA.
Methods : one hundred patients with a history of URSA referring to Obstetrics Clinic affiliated to Shiraz University of Medical Sciences between 2004 and 2009 were randomly divided into two groups.
Fifty patients in thromboprophylaxis group were treated with LMWH (5000 unit ; twice a day), ASA (80 mg daily) and calcium supplement (500 mg daily) after detection of fetal heart beat.
Another 50 patients received no thromboprophylaxis.
Live birth rate, obstetrical complications, prenatal and neonatal complications and hemorrhagic side effects were recorded.
Results : both groups were matched for mean age and mean number of pervious abortions.
Thromboprophylaxis group had a higher rate of live birth (83.7%) in comparison to the control group (54%).
No maternal or neonatal side effects were seen.
There were no differences in obstetrical complications, prenatal and neonatal complications between the two groups.
Conclusion : Thromboprophylaxis with ASA and LMWH seems to be safe and effective in patients with URSA.
American Psychological Association (APA)
Zolghadri, J.& Pour, F. Ahmad& Momtahan, M.& Tavana, Z.& Foroughinia, L.. 2010. Evaluation of the efficacy of aspirin and low molecular weight heparin in patients with unexplained recurrent spontaneous abortions. Iranian Red Crescent Medical Journal،Vol. 12, no. 5, pp.548-552.
https://search.emarefa.net/detail/BIM-252272
Modern Language Association (MLA)
Zolghadri, J.…[et al.]. Evaluation of the efficacy of aspirin and low molecular weight heparin in patients with unexplained recurrent spontaneous abortions. Iranian Red Crescent Medical Journal Vol. 12, no. 5 (Sep. 2010), pp.548-552.
https://search.emarefa.net/detail/BIM-252272
American Medical Association (AMA)
Zolghadri, J.& Pour, F. Ahmad& Momtahan, M.& Tavana, Z.& Foroughinia, L.. Evaluation of the efficacy of aspirin and low molecular weight heparin in patients with unexplained recurrent spontaneous abortions. Iranian Red Crescent Medical Journal. 2010. Vol. 12, no. 5, pp.548-552.
https://search.emarefa.net/detail/BIM-252272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 551-552
Record ID
BIM-252272