The effect of maternal selenium supplementation on pregnancy outcome and the level of oxidative stress in neonates
Joint Authors
Boskabadi, H.
Rezagholizade, F.
Tara, F.
Rayman, M. P.
Ghayour-Mobarhan, M.
Sahebkar, A.
Tavallaie, S.
Alamdari, D. H.
Kiani, Mehrzad
Razavi, B. S.
Oladi, M.
Ferns, G.
Shakeri, M. T.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 12, Issue 3 (31 May. 2010), pp.254-259, 6 p.
Publisher
Publication Date
2010-05-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : pregnancy is regarded as a condition which is usually accompanied by oxidative stress.
This study was undertaken to investigate the effect of maternal selenium supplementation during gestation on the level of oxidative stress in neonates and the pregnancy outcome.
Methods : in this double-blind trial, 179 prim gravid pregnant women in the first trimester of pregnancy were randomly assigned to receive 100 μg of selenium (Se group) or a placebo (control group) per day until delivery.
The level of oxidative stress and serum selenium concentration was determined in the maternal and umbilical cord sera of the subjects.
Oxidative stress was measured by means of a novel assay of provident-antioxidant balance (PAB).
The incidence of any pregnancy complications and outcomes was also evaluated in all neonates, being fully examined and followed up until 45 days.
Results : although maternal selenium concentration was significantly higher in the Se group (p < 0.001), there was no statistically significant differences in the umbilical cord selenium content between the two groups.
Selenium supplementation was not associated with any significant decrease in PAB values in the Se group.
The incidence of neonatal complications and outcomes did not differ significantly between the groups.
Conclusion : maternal selenium supplementation during pregnancy was safe but was not associated with a significant change in the extent of oxidative stress in neonates.
American Psychological Association (APA)
Tavallaie, S.& Shakeri, M. T.& Alamdari, D. H.& Kiani, Mehrzad& Razavi, B. S.& Oladi, M.…[et al.]. 2010. The effect of maternal selenium supplementation on pregnancy outcome and the level of oxidative stress in neonates. Iranian Red Crescent Medical Journal،Vol. 12, no. 3, pp.254-259.
https://search.emarefa.net/detail/BIM-252765
Modern Language Association (MLA)
Tavallaie, S.…[et al.]. The effect of maternal selenium supplementation on pregnancy outcome and the level of oxidative stress in neonates. Iranian Red Crescent Medical Journal Vol. 12, no. 3 (May. 2010), pp.254-259.
https://search.emarefa.net/detail/BIM-252765
American Medical Association (AMA)
Tavallaie, S.& Shakeri, M. T.& Alamdari, D. H.& Kiani, Mehrzad& Razavi, B. S.& Oladi, M.…[et al.]. The effect of maternal selenium supplementation on pregnancy outcome and the level of oxidative stress in neonates. Iranian Red Crescent Medical Journal. 2010. Vol. 12, no. 3, pp.254-259.
https://search.emarefa.net/detail/BIM-252765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 259
Record ID
BIM-252765