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Interleukin-12 and tumor necrosis factor-β gene polymorphisms as genetic susceptibility factors for brucellosis in iranian patients
Joint Authors
Rasouli, M.
Kiany, S.
Moravej, A.
Kalani, M.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 12, Issue 3 (31 May. 2010), pp.266-271, 6 p.
Publisher
Publication Date
2010-05-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : some reports suggest that the cytokine gene polymorphisms can contribute to the resistance or susceptibility to brucellosis.
The aim of this study was to find out any probable association of genetic polymorphisms of Interleukin - 12 (+ 1188 A / C) and TNF-β (+ 252 A / G) with susceptibility to the disease.
Methods : one hundred and ninety-six patients with brucellosis and 81 healthy farmers (controls) who owned infected animals and consumed their contaminated dairy products were included in this study.
IL-12 (+ 1188 A / C) and TNF-β (+ 252 A / G) genotyping were carried out for all of the subjects.
Results : the results showed that the frequencies of IL-12 AA genotype and A allele were higher in controls than in patients while TNF-β AA genotype and A allele were significantly higher in patients compared to the controls.
Conclusion : these findings suggest that the inheritance of the above-mentioned genotypes and alleles can be considered as genetic factors conferring resistance or susceptibility to brucellosis.
American Psychological Association (APA)
Rasouli, M.& Kiany, S.& Moravej, A.& Kalani, M.. 2010. Interleukin-12 and tumor necrosis factor-β gene polymorphisms as genetic susceptibility factors for brucellosis in iranian patients. Iranian Red Crescent Medical Journal،Vol. 12, no. 3, pp.266-271.
https://search.emarefa.net/detail/BIM-252785
Modern Language Association (MLA)
Kalani, M.…[et al.]. Interleukin-12 and tumor necrosis factor-β gene polymorphisms as genetic susceptibility factors for brucellosis in iranian patients. Iranian Red Crescent Medical Journal Vol. 12, no. 3 (May. 2010), pp.266-271.
https://search.emarefa.net/detail/BIM-252785
American Medical Association (AMA)
Rasouli, M.& Kiany, S.& Moravej, A.& Kalani, M.. Interleukin-12 and tumor necrosis factor-β gene polymorphisms as genetic susceptibility factors for brucellosis in iranian patients. Iranian Red Crescent Medical Journal. 2010. Vol. 12, no. 3, pp.266-271.
https://search.emarefa.net/detail/BIM-252785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 267
Record ID
BIM-252785