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Association between mdr1 c3435t gene polymorphism and acute lymphoblastic leukemia (ALL) in iranian population
Joint Authors
Miladpoor, B.
Behravan, J.
Nejatshokouhi, A.
Banihashem, A.
Smaili, H.
Meshkibaf, M. H.
Ataollahi, M. R.
Khedri, A.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 12, Issue 3 (31 May. 2010), pp.277-281, 5 p.
Publisher
Publication Date
2010-05-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : P-glycoprotein (P-gp), an ATP-dependent efflux pump, is a membrane protein encoded by MDR1 gene.
P-gp has an important role in protection of the cell against xenobiotic and toxic compounds.
Recently, a silent C3435T polymorphism in exon 26 of MDR1 has been reported to be associated with a decreased expression of P-gp in TT genotypes carriers compared with CC genotypes carriers.
Methods : to evaluate the distribution of allelic variants of C3435T MDR1 in a group of healthy population in Iran and find the association between MDR1 C3435T polymorphism and the incidence of ALL, 126 patients with ALL and 139 healthy controls were included in our study and their MDR1 polymorphisms were detected by PCRRFLP assay.
Results : 71.9% of the healthy people had 3435TC genotype, 15.8% had 3435TT genotype and 12.2% had 3435CC genotype.
Also, the frequency of T allele was 51.8 % and C allele 48.2%.
The mutant homozygous TT and TC genotypes were found to be associated with the incidence of ALL (OR = 1.96 for TT genotype and OR = 0.53 for TC genotype).
Conclusion : MDR1 C3435T polymorphism may contribute to the incidence of ALL.
TT genotypes carriers are more at risk of developing ALL than other genotypes carriers.
American Psychological Association (APA)
Miladpoor, B.& Behravan, J.& Nejatshokouhi, A.& Banihashem, A.& Smaili, H.& Meshkibaf, M. H.…[et al.]. 2010. Association between mdr1 c3435t gene polymorphism and acute lymphoblastic leukemia (ALL) in iranian population. Iranian Red Crescent Medical Journal،Vol. 12, no. 3, pp.277-281.
https://search.emarefa.net/detail/BIM-252809
Modern Language Association (MLA)
Nejatshokouhi, A.…[et al.]. Association between mdr1 c3435t gene polymorphism and acute lymphoblastic leukemia (ALL) in iranian population. Iranian Red Crescent Medical Journal Vol. 12, no. 3 (May. 2010), pp.277-281.
https://search.emarefa.net/detail/BIM-252809
American Medical Association (AMA)
Miladpoor, B.& Behravan, J.& Nejatshokouhi, A.& Banihashem, A.& Smaili, H.& Meshkibaf, M. H.…[et al.]. Association between mdr1 c3435t gene polymorphism and acute lymphoblastic leukemia (ALL) in iranian population. Iranian Red Crescent Medical Journal. 2010. Vol. 12, no. 3, pp.277-281.
https://search.emarefa.net/detail/BIM-252809
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 281
Record ID
BIM-252809