Evaluation of CD31 expression and mast cell count in dysplastic lesions and squamous cell carcinoma of the Oral Cavity
Joint Authors
Mushrif, M.
Ashkavandi, Z. Jaafari
Mashhadi-Abbas, F.
Sargolzaie, S.
Taghavi, N.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 12, Issue 3 (31 May. 2010), pp.272-276, 5 p.
Publisher
Publication Date
2010-05-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : سquamous cell carcinoma (SCC) is the most common malignancy in the oral cavity.
Angiogenesis is essential for development and progression of SCC.
Recently, some studies have reported that mast cells play a role in tumor progression, via promoting angiogenesis.
The aim of this study was to determine CD31 (an endothelial marker) expression and mast cell count in oral dysplastic lesions and SCC.
Methods : the CD31 expression and mast cell count were investigated in paraffin-embedded specimens of 10 cases of fibroma (control group), 10 cases of epithelial dysplasia, and 20 cases of SCC.
CD31 expression was examined by IHC and mast cell count was evaluated by Giemsa staining.
Results : the mean of CD31 expression did not show any significant difference between groups, but in the tumors, peritumoral stream revealed a significantly higher CD31 expression than intratumoral stream.
A significant difference in the mast cell count was observed between the groups and between peri- and intratumoral stream of SCCs.
Conclusion : the mean of CD31 expression and mast cell count did not show any correlation.
Pre- and post-treatment studies and double staining methods are suggested for more definitive results.
American Psychological Association (APA)
Ashkavandi, Z. Jaafari& Mushrif, M.& Mashhadi-Abbas, F.& Sargolzaie, S.& Taghavi, N.. 2010. Evaluation of CD31 expression and mast cell count in dysplastic lesions and squamous cell carcinoma of the Oral Cavity. Iranian Red Crescent Medical Journal،Vol. 12, no. 3, pp.272-276.
https://search.emarefa.net/detail/BIM-252949
Modern Language Association (MLA)
Ashkavandi, Z. Jaafari…[et al.]. Evaluation of CD31 expression and mast cell count in dysplastic lesions and squamous cell carcinoma of the Oral Cavity. Iranian Red Crescent Medical Journal Vol. 12, no. 3 (May. 2010), pp.272-276.
https://search.emarefa.net/detail/BIM-252949
American Medical Association (AMA)
Ashkavandi, Z. Jaafari& Mushrif, M.& Mashhadi-Abbas, F.& Sargolzaie, S.& Taghavi, N.. Evaluation of CD31 expression and mast cell count in dysplastic lesions and squamous cell carcinoma of the Oral Cavity. Iranian Red Crescent Medical Journal. 2010. Vol. 12, no. 3, pp.272-276.
https://search.emarefa.net/detail/BIM-252949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 276
Record ID
BIM-252949