Antitumor activity of rheum ribes and thymus syriacus im male albino mice

Abstract EN

To search for possible chemo preventive agents from natural resources, the aqueous extracts of Rhaum ribes (Rhubarb) and Thymus Syracuse (Thyme) with the concentrations 1 %, 5 %, and 5%, 7.5 % respectively were used via drinking water for 25 weeks to test its inhibitory role on skin tumors of male Swiss albino mice initiated with applied 7,12-dimethylbenz(a) anthracite (DMBA) on the dorsal skin.

Mice were promoted by twice weekly application of benzoyl peroxide for 25 weeks.

At the end of the experiment the animals were sacrificed and sections of skin were histologically studied.

The result revealed that both plant extracts showed significant reduction in the number of mouse with tumors (incidence) and the number of tumors per mouse 'multiplicity) induced by DMBA.

Histological investigations indicated that rhubarb extract reduced squamous papilloma's *JS^ simulated hair follicle proliferation.

Thyme extracts also reduced squamous papilloma's verse result suggest that rhubarb root arid thyme leaves extract might be valuable as chemo Inventive agent for chemical carcinogenesis.