In vitro evaluation of tinidazole bioadhesive vaginal gels

Abstract EN

Many trials were made to prepare Tinidazole 2% as bio adhesive vaginal gels using different gel bases including hydroxypropyl methyl cellulose (3 and 4% w / w), methylcellulose (3 and 4%w / w) and carboxymethylcellulose (2 and 3% w / w).

Swelling index of the polymers, pH, viscosity, bio adhesive force, and in-vitro drug release to the simulating vaginal fluid (S.

V.

F.) were investigated for all the prepared bio adhesive gels.

The mechanism of drug release from the gel bases was also investigated.

The results revealed that C MC 3% gave the highest viscosity and bio adhesive strength with the lowest release rate while lowest viscosity and bio adhesive force was obtained with HPMC gel base with the highest release rate.

The mechanism of drug release was affected by the type of gel base.

Fick Ian diffusion was obtained with all gel bases.