A qsar study on benzoxazinones, analogues of efavirenz, for the discovery of potent hiv-1reversrse transcriptase inhibitors
Joint Authors
Srivastava, A. K.
Chaurasia, Shraddha
Khan, Arbab A.
Tripathi, Abha
Source
Journal of Saudi Chemical Society
Issue
Vol. 9, Issue 3 (28 Feb. 2005), pp.571-574, 4 p.
Publisher
Publication Date
2005-02-28
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract AR
تم تحليل نشاط مضاد HIV-1 للبتروكسازينونات, المماثل ل Efavirenz و ذلك بالنسبة للخواص الفيزكيميائية و الجزئية, وقد وجد أن فعالية المركبات تتعلق بشكل ملحوظ بالمعامل الفراغي, التوصيلية الجزيئية v1, عدم حب الماء و المعامل الإلكتروني المتعلق بالسالبية الكهربية Xeq.
و وجد أن النتائج مفيدة في مناقشة ميكانية تفاعل مستقبل الدواء.
Abstract EN
The anti HIV-1 activity of Benzoxazinones, analogues of Efavirenz, is analyzed in relation to their physicochemical and molecular properties.
The activities of the compounds are found to be significantly correlated with steric parameter, molecular connectivity 1 X v, hydrphobicity-log P and electronic parameter equalized electro negativity-Xeq.
The results are found to be useful in disussing the mechanism of drug-receptor interaction.
American Psychological Association (APA)
Srivastava, A. K.& Khan, Arbab A.& Tripathi, Abha& Chaurasia, Shraddha. 2005. A qsar study on benzoxazinones, analogues of efavirenz, for the discovery of potent hiv-1reversrse transcriptase inhibitors. Journal of Saudi Chemical Society،Vol. 9, no. 3, pp.571-574.
https://search.emarefa.net/detail/BIM-25661
Modern Language Association (MLA)
Srivastava, A. K.…[et al.]. A qsar study on benzoxazinones, analogues of efavirenz, for the discovery of potent hiv-1reversrse transcriptase inhibitors. Journal of Saudi Chemical Society (Feb. 2005), pp.571-574.
https://search.emarefa.net/detail/BIM-25661
American Medical Association (AMA)
Srivastava, A. K.& Khan, Arbab A.& Tripathi, Abha& Chaurasia, Shraddha. A qsar study on benzoxazinones, analogues of efavirenz, for the discovery of potent hiv-1reversrse transcriptase inhibitors. Journal of Saudi Chemical Society. 2005. Vol. 9, no. 3, pp.571-574.
https://search.emarefa.net/detail/BIM-25661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 574
Record ID
BIM-25661
