Comparative study of the renoprotective effects of captopril and aminophylline against cainst cisplatin-induced nephrotoxicty in rats

Abstract EN

Background : Cisplatin is one of the most commonly used anti-cancer drugs, but its clinical use was limited by its nephrotoxicity.

Methods : In this study ‘we try to investigate the renoprotective effect of captopril and aminophylline against cisplatin induced nephrotoxicity.

For this purpose a 36 Sprague Dawley rats was divided randomly to 6 groups, each group consist of 6 rats.

The first group given normal saline and act as control group, while the other 5 groups given cisplatin ( 7.5 mg / kg ), captopril ( 60 mg / kg ), aminophylline ( 24 mg / kg ), captopril with cisplatin and aminophylline with cisplatin respectively.

All drugs are given as single dose through intraperitonial route.

After 6 days blood urea and serum creatinine, malondialdehyde and glutathione are measured and compared with control group.

Results : The data show that both captopril and aminophylline posses renoprotective effect against cisplatin-induced nephrotoxicity, also the data show that captopril renoprotective effect is more than that produced by aminophylline.

Conclusions : This data can help in increase the dose of cisplatin in clinical uses together with use of renoprotective agent, especially if the patient already need such renoprotective drugs for treatment of disease a way from cisplatin as hypertension .Also more clinical studies required for more assessment of the clinical pattern of this renoprotective effect .