The influences of aminophylline and indomethacin in glycerol-induced acute renal failure in rate

Abstract EN

Background : Adenosine mediates homodynamic changes and resulted in the production of acute renal failure (ARF) in female Albino-Wister rats, therefore, adenosine level increases highly in ARF.

Objective : This experiment was designed to investigate the effect of the adenosine antagonist aminophylline and the adenosine agonist indomethacin on glycerol-induced ARF.

Method : Glycerol induced ARF was produced by a single dose (10ml / kg, 50% v / v with tap water, IM)in rats, which were restricted to drinking water.

Aminophylline was used in our study in a dose of 25mg / kg, LP) while the dose of indomethacin was 10mg / kg, LP).

Results: Aminophylline exert its protective effect against glycerol induced-ARF by lowering the elevation in concentrations of blood urea nitrogen (BUN), serum creatinine (Scr), and mortality rate with a markedly attenuation of the sever impairment of creatinine clearance (Ccr).

On the other hand, indomethacin potentiates glycerol induced-ARF by significantly increase the elevation in concentrations of BUN, Scr and mortality rate with severely suppressed the decrement in Ccr.

Conclusion: Aminophylline has ameliorating effect on glycerol induced ARF while the prostaglandin inhibitor indomethacin has reversed effect.