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Effect of very early atorvastatin initiation for acute myocardial infarction on creatine kinase release
Joint Authors
Abd al-Aziz, Luayy S.
Abd al-Karim, Faris
al-Adeem, Adnan A.
Source
al-Kindy College Medical Journal
Issue
Vol. 6, Issue 1 (30 Jun. 2010), pp.79-84, 6 p.
Publisher
University of Baghdad al-Kindi College of Medicine
Publication Date
2010-06-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : It has been suggested that pre-treatment with a statin agent prior to myocardial infarction limits myocardial creatine kinase release, and thus may act to limit myocardial infarct size in humans.
Objective : To examine the effect of very early statin, initiation for acute myocardial infarction (AMI), to the extent of myonecrosis as manifested by peak serum creatine kinase levels.
Methods : Patients with AMI admitted to Al-Kindy teaching hospital cardiac care unit from 1st February 2007 to 28th February 2008, who fulfilled the inclusion criteria cited in the present study, were randomly assigned into two study groups.
The statin group patients have received a single oral dose of 40 mg itorvastatin at time of admission and repeated for the next days until discharge, patients not receiving statin were considered as controls, blood samples were obtained on admission and every 8 h for another three consecutive samples to identify peak creatine kinase levels.
Results : Patients who had statin therapy initiated immediately after hospital admission have similar peak creatine kinase concentrations as compared to those not receiving statin therapy (P = 0.332).
Conclusion : statin initiation in AMI patients fails to show any observable effect on creatine kinase release, the need of an extended period for the statin agent to achieve the predictable outcome may suggest the necessity of statin pretreatment in patients at high risk for AMI.
American Psychological Association (APA)
Abd al-Karim, Faris& Abd al-Aziz, Luayy S.& al-Adeem, Adnan A.. 2010. Effect of very early atorvastatin initiation for acute myocardial infarction on creatine kinase release. al-Kindy College Medical Journal،Vol. 6, no. 1, pp.79-84.
https://search.emarefa.net/detail/BIM-256896
Modern Language Association (MLA)
al-Adeem, Adnan A.…[et al.]. Effect of very early atorvastatin initiation for acute myocardial infarction on creatine kinase release. al-Kindy College Medical Journal Vol. 6, no. 1 (Jun. 2010), pp.79-84.
https://search.emarefa.net/detail/BIM-256896
American Medical Association (AMA)
Abd al-Karim, Faris& Abd al-Aziz, Luayy S.& al-Adeem, Adnan A.. Effect of very early atorvastatin initiation for acute myocardial infarction on creatine kinase release. al-Kindy College Medical Journal. 2010. Vol. 6, no. 1, pp.79-84.
https://search.emarefa.net/detail/BIM-256896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 81-83
Record ID
BIM-256896