Has exogenous melatonin induce histological changes in collecting tubules and ducts of rat's kidney?

Abstract EN

Background : Selective re-absorption and secretion are the functions of the collecting tubules and ducts, in addition to concentrate urine through anti diuretic hormone ( ADH)-regulated and anti diuretic hormone( ADH)-independent water channels.

Methods : Twenty four male albino rats were used, they were divided into two groups: Group (A) included twelve rats of five weeks old age (before puberty) that were divided into three subgroups, four rats in each subgroup.

Subgroup I was control one, subgroups II and III were treated orally with melatonin in a dose of 250 and 500 µg / kg body weights subsequently.

Group (B) included twelve rats of seventeen weeks old age (after puberty) that were divided into the same subgroups and treated with the doses of melatonin as in the rats of group (A).

Results : The exogenous melatonin induced structural changes on the collecting tubules, in dose dependent manner as well as onset-dependent manner whether used in pre-or post-puberty of male albino rats.

Conclusion : the study reflected the nephrotoxic effects of different oral doses of exogenous melatonin on collecting tubules and ducts on different age groups regarding sexual maturation of rats, exogenous melatonin which is a nephrotoxic agent in a dose -dependent manner.