Ynthesis, characterization and antimicrobial activity study via some new schiff bases for trimethoprim
Joint Authors
Kazim, Nafisah Jabbar
Zahir, Saadiyah Ahmad
al-Sahib, Sana Abd
Abd al-Razzaq, Wasan
Source
Publisher
University of Baghdad College of Science for Women
Publication Date
2010-03-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Arabic Abstract
تم في هذا البحث تحضير أنواع من قواعد شف جديدة للمركب الدوائي التراي مثبرين المعروف بفعاليته الدوائية العالية من خلال تكثيف التراي مثبرين مع بعض الالدهايدات (4- ثنائي مثيل أمينو بنزلديهايد، بروبانال، سلسلك الدهايد, 2.4 ثنائي ميثوكسي بنزلديهايد، 4- مثيل بنزلديهايد) لنحصل على نواتج قواعد شف (5a-1a).
و الكيتونات (4-أمينو اسيتوفينون,4-كلورو اسيتوفينون, أزوبيوتايل كيتون, استايل اسيتون, و اسيتوفينون) لنحصل على نواتج قواعد شف (10b-6b) بوجود حامض الكبريتيك كعامل مساعد و بوجود الإيثانول كمذيب.
تم تشخيص المركبات المحضرة باستخدام بعض الطرق الطيفية UV-Visible, FTIR الأنشطة البايولوجية قد تم بحثها أيضا لهذه مركبات مع البكتريا الموجبة bacillusو البكتريا السالبة E-Coli.f .
حيث تبين أن معظم المركبات تحت البحث لها فعالية تثبيط.
English Abstract
This search reports the synthesis of some new series of Schiff base compounds for trimethoprim derivatives which known high been known as a medicinal effectiveness.
Trimethoprim was condensed with several substituted aldehydes compounds.
(4-dimethyl amine Benz aldehyde, propanol, Salic aldehyde, 2.4 dimethyl Benz aldehyde and 4- methyl Benz aldehyde) to obtain Schiff base products (la-5a) and several substituted ketones compound (4-aminoacetophenone,4-chloroacetophenone, isobutyl ketone, acetyl acetone and acetophenone) to obtain Schiff base products(6b-10b) in ethanol in the presence of concentrated su0lphuric acid as a catalyst to yield the Schiff base.
The structure of synthesized compounds has been established on the basis of their Chemical structures of all products were confirmed by spectrophotometric methods such as U.V.
visible and FTIR..
All these compounds were evaluated for their antibacterial activity in vitro against Gram + ve bacteria (bacillus), Gram - ve bacteria (E-Coli).Most Compound under investigation exhibited potent antibacterial activity.
Data Type
Conference Papers
Record ID
BIM-257222
American Psychological Association (APA)
Zahir, Saadiyah Ahmad& al-Sahib, Sana Abd& Abd al-Razzaq, Wasan& Kazim, Nafisah Jabbar. 2010-03-31. Ynthesis, characterization and antimicrobial activity study via some new schiff bases for trimethoprim. Scientific Conference for Women : Chemistry (1st : 2012 : Baghdad, Iraq). . Vol. 7, no. 1 (2010), pp.614-620.Baghdad Iraq : University of Baghdad College of Science for Women.
https://search.emarefa.net/detail/BIM-257222
Modern Language Association (MLA)
Zahir, Saadiyah Ahmad…[et al.]. Ynthesis, characterization and antimicrobial activity study via some new schiff bases for trimethoprim. . Baghdad Iraq : University of Baghdad College of Science for Women. 2010-03-31.
https://search.emarefa.net/detail/BIM-257222
American Medical Association (AMA)
Zahir, Saadiyah Ahmad& al-Sahib, Sana Abd& Abd al-Razzaq, Wasan& Kazim, Nafisah Jabbar. Ynthesis, characterization and antimicrobial activity study via some new schiff bases for trimethoprim. . Scientific Conference for Women : Chemistry (1st : 2012 : Baghdad, Iraq).
https://search.emarefa.net/detail/BIM-257222
