Construction of phenytoin selective electrodes and its application to pharmaceutical preparation
Other Title(s)
بناء قطب الفنيتون الانتقالي لتقدير الفنيتون في المواد الصيدلانية
Joint Authors
Sayhud, Suhaylah Kazim
Nassury, Nabil Shawkat
al-Haydari, Abd al-Muhsin
Source
Publisher
University of Baghdad College of Science for Women
Publication Date
2010-03-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Arabic Abstract
في هذه الدراسة حضرت أقطاب انتقائية للفنيتون معتمدة على معقد الدواء مع dodeca-Tungstophpsphoric acid و مجموعة من المواد الملدنة Di-buty1 phthalate (DBPH), Di-byty1 phosphate (DBP), Tri-buty1 phosphate (TBP), O-nitro pheny1 octy1 ether (ONOPE)، أظهرت النتائج أن أقطاب الفنيتون مع الملدنات (DBPH) و ONPOE أعطت انحدارا = 56.4, 55.3 mV / decade على التوالي و مدى تركيز خطي 1×10-1-1×10-4 وحد تححسس 1.9×10-4.
أما أقطاب المعتمدة على الملدنات و TBP و DBP أعطت انحدارا لانرنستي mV / decade 40.5, 40.2 على التوالي.
أظهرت الدراسة عدم وجود تداخل للعدد من الأيونات الموجبة الأحادية و الثنائية و الثلاثية.
لدراسة الخواص العملية في محاليل قياسية محضرة مختبريا و كذلك في نماذج دوائية تم استعمال الأقطاب كأقطاب كاشفة في عملية التسحيح النرنستي و استعملت طريقة الإضافات القياسية لنماذج دوائية للفنيتون.
English Abstract
Phenytoin selective electrodes were constructed based on penytoin-phosphotungstate (Ph-PT) complex with different plasticizers; di-butyl phosphate (DBP), tri-butyl phosphate (TBP), di-butyl phthalate (DBPH), and o-nitro phenyl octyl ether (NPOE) phthalate.
The electrodes based on DBPH, ONPOE plasticizers gave Narnistain slope which are, 56.4 and 55.3mV/decade with detection limit of 1.9xl0"5M , 1.8xlO"5 and concentration range 10"1 to 10"4 M and pH range 3.0- 8.0.
The electrodes based on TBP and DBP showed non-Nernistain slopes, 40.2, 40.5 mV/decade for both plasticizers.
Interfering of some captions was investigated and shows no interfering with electrodes response.
Potentiometric methods were used for measuring phenytoin in pharmaceutical drugs (tablets) and the electrode based on DBPH was used for determination.
The recovery obtained from measuring was in good agreements with that given in British Pharmacopeias.
Data Type
Conference Papers
Record ID
BIM-257313
American Psychological Association (APA)
Sayhud, Suhaylah Kazim& Nassury, Nabil Shawkat& al-Haydari, Abd al-Muhsin. 2010-03-31. Construction of phenytoin selective electrodes and its application to pharmaceutical preparation. Scientific Conference for Women : Chemistry (1st : 2012 : Baghdad, Iraq). . Vol. 7, no. 1 (2010), pp.687-695.Baghdad Iraq : University of Baghdad College of Science for Women.
https://search.emarefa.net/detail/BIM-257313
Modern Language Association (MLA)
Sayhud, Suhaylah Kazim…[et al.]. Construction of phenytoin selective electrodes and its application to pharmaceutical preparation. . Baghdad Iraq : University of Baghdad College of Science for Women. 2010-03-31.
https://search.emarefa.net/detail/BIM-257313
American Medical Association (AMA)
Sayhud, Suhaylah Kazim& Nassury, Nabil Shawkat& al-Haydari, Abd al-Muhsin. Construction of phenytoin selective electrodes and its application to pharmaceutical preparation. . Scientific Conference for Women : Chemistry (1st : 2012 : Baghdad, Iraq).
https://search.emarefa.net/detail/BIM-257313
