Chlamydophila pneumoniae DNA in coronary atherosclerotic : a causal association
Joint Authors
Mahmud, Kamal
al-Shazili, Muhammad
Salih, Izz al-Din
Fadaly, Gilan A.
Source
Journal of the Medical Research Institute
Issue
Vol. 29, Issue 2 (30 Jun. 2008), pp.132-139, 8 p.
Publisher
Alexandria University Medical Research Institute
Publication Date
2008-06-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : Association between infection by Chlamydophila pneumoniae 'Chlamydia pneumoniae' (C.
pneumoniae) and atherosclerosis has been frequently reported.
Molecular techniques as Polymerase chain reaction (PCR) has been used by many researchers for detection of C.
pneumoniae DNA in atherosclerotic plaques with variable prevalence rates.
Methods :This study investigated the presence of C.
pneumoniae DNA, by using PCR, in coronary atherosclerotic plaques surgically removed from patients undergoing coronary artery bypass grafting (CABG) histopathological study of the plaques was also performed.
In addition, the association between the serum levels of high-sensitivity C-reactive protein (hsCRP), fibrinogen and the presence of C.
pneumoniae DNA in coronary atherosclerotic plaques was also studied.
Results : Revealed the presence of C.
pneumoniae DNA in 56.5% of the studied atherosclerotic plaques and that its presence was significantly associated with chronic inflammatory cell infiltrate, and high levels of hsCRP.
Conclusion: The results point to the likelihood of involvement of C.
pneumoniae in the pathogenesis of coronary atheroma rather than being a mere association
American Psychological Association (APA)
Salih, Izz al-Din& Mahmud, Kamal& al-Shazili, Muhammad& Fadaly, Gilan A.. 2008. Chlamydophila pneumoniae DNA in coronary atherosclerotic : a causal association. Journal of the Medical Research Institute،Vol. 29, no. 2, pp.132-139.
https://search.emarefa.net/detail/BIM-258283
Modern Language Association (MLA)
Salih, Izz al-Din…[et al.]. Chlamydophila pneumoniae DNA in coronary atherosclerotic : a causal association. Journal of the Medical Research Institute Vol. 29, no. 2 (2008), pp.132-139.
https://search.emarefa.net/detail/BIM-258283
American Medical Association (AMA)
Salih, Izz al-Din& Mahmud, Kamal& al-Shazili, Muhammad& Fadaly, Gilan A.. Chlamydophila pneumoniae DNA in coronary atherosclerotic : a causal association. Journal of the Medical Research Institute. 2008. Vol. 29, no. 2, pp.132-139.
https://search.emarefa.net/detail/BIM-258283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 137-139
Record ID
BIM-258283