Novel approach for heterocyclization : A clean and efficient synthesis and biological evaluation of 4-oxothiazolidines under microwave technique

Abstract EN

A new selective method has been developed for rapid synthesis of 2-(aryl)-3-[(2-benzoimidazolylthio) acetamidyl]-4-oxo-thiazolidines 4a-j by the heterocyclization of 2-{(1H-benzimidazol)-ylthio}-N-benzylidene aceto hydrazide 3a-j with HSCH2COOH under microwave irradiation (MWI) is described.

The reaction rate and yield is enhanced tremendously under MWI as compared to conventional methods.

All the compounds have been screened for their antifungal activity against Candida albicans and Aspergillus niger, antibacterial activity against Escherchia coli and Staphylococcus aureus.

In the primary screening, some of the compounds exhibited appreciable activity.

The structures of the synthesised compounds 4a-j have been characterized on the basis of their elemental analysis, IR, 1H NMR and Mass spectral data.