Antibodies against erythrocytes enhance invasion of mouse reticulocytes

Abstract EN

Twenty mice were injected i.

p.

with lxlO5 P.

berghei infected red cells.

Blood smears of these mice were prepared daily till the mice were died.

Mice were categorized in three groups depending on similar type of course of parasitaemia after inoculation.

Seven mice of Group A (A1-A7) showed similar type of behavior and died due to low parasite infection.

Another group of seven mice (B1 to B7) showed a gradual increase in parasitaemia till mice died due to high infection.

Group C (C1 to C6) smears showed a vary rise and fall in infection and all the mice were cleared of parasite infection.

The antibody titre as detected by IFA, observed in these groups was 1 : 2048 , 1 : 1024 and 1 : 4096 in groups A, B and C respectively.

The group C which showed protective immunity against P.

berghei infection depicted strong fluorescence against normal erythrocyte membrane too.

The fluorescence against normal RBCs membrane was observed very weak in group A, whereas it was negligible in group B.