Role of bacteria in urolithiasis : in vivo study

Abstract EN

The different bacterial species that were isolated from human renal stones : Pseudomonas aeruginosa (urease +ve), Proteus mirabilis, Citrobacter freundii, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, (urease -ve), and Escherichia coli, succeeded in stone formation in rats' kidneys, this was determined by examining tissue sections of the kidneys.

However, urease producing bacteria revealed more severe than non-urease ones, which influenced, markedly, in increasing urine volume after 10 days of bacterial injecting followed by a decline after 20 - 30 days, however, pH was acidic during the first ten days of injection, changed to alkalinity later, whereas those had been injected with non-urease producers, did not show such changes in their urine.