Evaluation of amitraz against ticks and mites infestation in cattle and sheep in comparison with diazinon and deltamethrin

Abstract EN

The pharmacokinetic profile of difloxacin was investigated in camels after single Intravenous and intramuscular administration of 5 mg kg-1 b.

wt.

After i.

v.

injection serum concentration time curve was best described as two compartment open model.

The distribution and elimination half-lives (t0.5 (α) and t0.5 (β)) were 0.513 ± 0.01 h and 6.3±0.15 h respectively.

Difloxacin was distributed extravascular with a volume of distribution (Vdss) 1.10 ± 0.035 l kg-1., and total body clearance (CLB) of 0.141 + 0.031 l kg-1 h-1.

Following intramuscular injection, peak serum concentration (C max) 2.59 ±0.19 ug ml-1 attained after T max 3.05 ± 0.035 h.

The absorption and elimination half-lives (t0.5 (ab) and t0.5 (el)) were 0.95 ± 0.003 and 5.86 ± 0.33 h., respectively.

The systemic bioavailability (F) and the plasma protein binding were 87.95 and 23 %, respectively.