Pharmacokinetics and bioavailability of difloxacin in camel

Abstract EN

The pharmacokinetic profile of difloxacin was investigated in camels after single Intravenous and intramuscular administration of 5 mg kg-1 b.

wt.

After i.

v.

injection serum concentration time curve was best described as two compartment open model.

The distribution and elimination half-lives (t0.5 (α) and t0.5 (β)) were 0.513 ± 0.01 h and 6.3±0.15 h respectively.

Difloxacin was distributed extravascular with a volume of distribution (Vdss) 1.10 ± 0.035 l kg-1., and total body clearance (CLB) of 0.141 + 0.031 l kg-1 h-1.

Following intramuscular injection, peak serum concentration (C max) 2.59 ±0.19 ug ml-1 attained after T max 3.05 ± 0.035 h.

The absorption and elimination half-lives (t0.5 (ab) and t0.5 (el)) were 0.95 ± 0.003 and 5.86 ± 0.33 h., respectively.

The systemic bioavailability (F) and the plasma protein binding were 87.95 and 23 %, respectively.