Histological and functional study of white male mice testes and kidney treated with tecrium polium aqueous extract

Abstract EN

The oral administration of the aqueous extract of Teucrium polium to a mature male mice in daily oral doses of 50 mg / kg body weight (group II) and 100 mg / kg body weight (group III) for eight consecutive weeks were resulted in significant increase (P<0.05) in the testicular weight in the treated groups in comparison with control.

The aqueous extract affected the spermatogenesis which demonstrated by an increase in leydig cell, spermatogonia, spermatocytes and spermatozoa.

The hormonal profile was influenced by the aqueous extract.

The testosterone level was significantly increased (P<0.05) in the treated groups, but no significant differences (P>0.05) in urea and uric acid levels between control and the treated groups were shown.

The kidneys of the group III were affected and showed degenerative changes and necrosis in nucleolus of cell of tubules and there is destruction in glumerular by increscent of mesenchymal cells.