Synthesis, characterization and biological studies of some N, O S containing compounds

Abstract EN

A series of biologically active compounds of the general formula, viz., RNHCOCH (SH) CH3 / RNHCOCH (OH) CH3 and R' [NHCOCH (SH) CH3] 2 / R' [NHCOCH (OH) CH3]2, where, R = –C6H5, –C6H4CH3, –C6H4Cl or–C6H4OCH3 and R' or (CH2) n when n = 2, 3 or 4; have been Synthesized and characterized by elernental analysis, infrared spectra, 1H-NMR spectra and molecular weight measurements.

These compounds are quite stable towards heat, light and air in the solid state.

The first series compounds are soluble in ethanol, whereas the second series compounds are highly soluble in water, less so in alcohol and acetone.

All these compounds were screened for their biological activity on different species of pathogenic fungi and bacteria and found sufficiently active.

The results indicate that some compounds show good antitumour activities in vitro.