Theoretical and synthetic approach towards the biology of some novel monobactam induced sulphonamides : assessing biology through coupling of active ingredients
Joint Authors
Ali, Parvez S.
Meshram, Jyotsna S.
Raut, Ravishankar D.
Source
Issue
Vol. 6, Issue 2 (30 Jun. 2011), pp.153-164, 12 p.
Publisher
Yarmouk University Deanship of Research and Graduate Studies
Publication Date
2011-06-30
Country of Publication
Jordan
No. of Pages
12
Main Subjects
Topics
Abstract EN
Novel monobactams were designed and synthesized by coupling the monocyclic azetidinones with sulphapyridine moiety in order to assess the possibility to enhance the bactericidal activity through a synergistic dual-action mechanism.
In a process, sulphapyridine (4) was condensed with different aromatic aldehydes to obtain anils 5 (a-h) which on Staudinger [2 + 2] cycloaddition with chloroacetyl chloride produced N-sulphapyridinyl-3-chloro-4- (substituted) azetidin-2-ones 6(a-h).
Their structures were confirmed by 1H-NMR, IR, Mass spectra and elemental analysis.
The activities were tested, in vitro, against a panel of selected bacteria.
A correlation of structure and activities relationship of these compounds with respect to molecular modeling, Lipinski rule of five, drug likeness, toxicity profiles and other physicochemical properties of drugs are described and verified experimentally.
American Psychological Association (APA)
Ali, Parvez S.& Meshram, Jyotsna S.& Raut, Ravishankar D.. 2011. Theoretical and synthetic approach towards the biology of some novel monobactam induced sulphonamides : assessing biology through coupling of active ingredients. Jordan Journal of Chemistry،Vol. 6, no. 2, pp.153-164.
https://search.emarefa.net/detail/BIM-264447
Modern Language Association (MLA)
Ali, Parvez S.…[et al.]. Theoretical and synthetic approach towards the biology of some novel monobactam induced sulphonamides : assessing biology through coupling of active ingredients. Jordan Journal of Chemistry Vol. 6, no. 2 (Jun. 2011), pp.153-164.
https://search.emarefa.net/detail/BIM-264447
American Medical Association (AMA)
Ali, Parvez S.& Meshram, Jyotsna S.& Raut, Ravishankar D.. Theoretical and synthetic approach towards the biology of some novel monobactam induced sulphonamides : assessing biology through coupling of active ingredients. Jordan Journal of Chemistry. 2011. Vol. 6, no. 2, pp.153-164.
https://search.emarefa.net/detail/BIM-264447
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 163-164
Record ID
BIM-264447