Evaluation of body Iron and oxidative stress status in smoker hypertensive diabetic patients suffering acute myocardial infarction episode

Abstract EN

The relationship between serum ferritin, body iron indices, and the coronary heart disease (CHD) or stroke remains controversial.

The role of diabetes mellitus, smoking, and hypertension on serum ferritin and other iron monitoring molecules in acute myocardial infarction (AMI) has been under active consideration.

The present study addresses the alterations in the body iron status and the lipid peroxidation (LPO) activity in AMI, particularly in the diabetics, hypertensive, and smokers.

The study also evaluates the correlation between them.

This study is comprised of AMI patients with or without diabetes / hypertension / smoking and healthy controls of ages 29 to 79.

Blood hemoglobin, hematocrit (HCT) values, serum iron, total iron binding capacity (TIBC), ferritin and erythrocytes LPO were analyzed.

An elevation in total iron, ferritin and erythrocyte LPO, and a decline in TIBC were observed in AMI patients irrespective of whether they are with or without diabetes, hypertension, or smoking while Haemoglobin (Hb) decreased in AMI non-smokers, and HCT remained unchanged when compared to controls.

A positive correlation existed between total iron, ferritin and erythrocyte LPO, between hemoglobin and hematocrit, but a negative correlation of TIBC with ferritin and LPO in the AMI experimental groups is observed.

A statistical significant increase in Hb and HCT values were noted in AMI smokers in comparison to AMI non-smokers, while other parameters remained unchanged between the complimentary AMI groups.

AMI females had lower levels of Hb and HCT than AMI males.

Diabetes, hypertension, smoking, and AMI are inflammatory processes.

Elevated Ferritin, an acute phase reaction protein and associated LPO activity might be attributed to AMI progression.