Screening of terminalia bellirica fruits extracts for its analgesic and antipyretic activities

Abstract EN

The study was designed to investigate the analgesic and antipyretic activities of ethanolic and aqueous extracts of Terminal Billerica (family : Combrataceae) fruits (200 mg/kg, p.o.) in acetic acid-induced writhing, Eddy’s hot plate method and brewer's yeast-induced fever models in mice and rats.

Both extracts showed a significant decrease in the number of the writhes in acetic acid-induced writhing and increase in paw licking time to heat stimuli in the hot plate method.

Both extracts showed a significant inhibition of elevated body temperature when compared to corresponding control.

The results suggested that the ethanolic and aqueous extracts possessed significant analgesic and antipyretic activities.