Comparative study between orchidectomy alone and orchidectomy with hormonal therapy (combined androgen blockade) for patients with advanced carcinoma of the prostate
Author
Source
Issue
Vol. 16, Issue 2 (30 Sep. 2010), pp.95-100, 6 p.
Publisher
University of Basrah College of Medicine
Publication Date
2010-09-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract EN
Worldwide, prostate cancer incidence and mortality vary significantly between countries and regions and are highest in African American men.
In the USA, prostate cancer is the most common visceral malignant neoplasm in men and the second leading cause of cancer-related deaths.
Bilateral orchidectomy with or without hormonal therapy are the main treatment options for patients with advanced prostate carcinoma.
The objective of this study is to compare the efficacy of orchidectomy alone and orchidectomy plus flu amide in treating patients with advanced carcinoma of prostate.
The study was conducted from June 2006 to March 2010.
Thirty six patients were included in the study.
The inclusion criteria were histologically documented carcinoma prostate along with distant metastasis (stage D2).
Following orchidectomy, the patients were stratified into two groups.
Group I had patients treated with orchidectomy alone (17 patients) and Group II those treated with orchidectomy plus flu amide therapy (19 patients).
Follow up of patients was done for the next two years following initiation of therapy.
The maximum percentage change in PSA was found in the first three months after orchidectomy.
The mean percentage change at two years, in the two groups was 65% and 62% respectively.
Based on the evaluation of response, there was no significant difference in response rate between the two treatment groups.
In conclusion, addition of antiandrogen like flu amide to orchidectomy has not given any significant benefit to effect the PSA changes as well the survival in advanced carcinoma of prostate.
Hence, routine use of additional antiandrogen to orchidectomy is not advisable.
American Psychological Association (APA)
Attar, Firas Shakir. 2010. Comparative study between orchidectomy alone and orchidectomy with hormonal therapy (combined androgen blockade) for patients with advanced carcinoma of the prostate. Basrah Journal of Surgery،Vol. 16, no. 2, pp.95-100.
https://search.emarefa.net/detail/BIM-265444
Modern Language Association (MLA)
Attar, Firas Shakir. Comparative study between orchidectomy alone and orchidectomy with hormonal therapy (combined androgen blockade) for patients with advanced carcinoma of the prostate. Basrah Journal of Surgery Vol. 16, no. 2 (Sep. 2010), pp.95-100.
https://search.emarefa.net/detail/BIM-265444
American Medical Association (AMA)
Attar, Firas Shakir. Comparative study between orchidectomy alone and orchidectomy with hormonal therapy (combined androgen blockade) for patients with advanced carcinoma of the prostate. Basrah Journal of Surgery. 2010. Vol. 16, no. 2, pp.95-100.
https://search.emarefa.net/detail/BIM-265444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 100
Record ID
BIM-265444