Neat reaction technology and conventional method for the synthesis of 4-OXO-thiazolidines and their 5-arylidene derivatives and its antimicrobial activity

Abstract EN

Several new 4-arylideneamino-3-mercapto-5-[(phenothiazin-10-yl) methyl]-1, 2, 4-triazoles5a-h, 2-aryl-3-(3-mercapto-5-phenothiazin-10-ylmethyl-[1, 2, 4]-triazol-4-yl)-thiazolidin-4-one 6a-h and 5-arylidene-2-aryl-3-(3-mercapto-5-phenothiazin-10-ylmethyl-[1, 2, 4]-triazol-4-yl)-thiazolidin-4-one 7a-h were synthesized under both conventional as well as microwave irradiation technique.

The structures of all synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, FAB- mass spectra and by micro analytical data.

All synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, Salmonella tophi and Bacillus subtitles and antifungal activity against Aspergillums flatus, Fusarium oxysporum and Penicillium citrinum.

Some of the compounds have shown significant antibacterial and antifungal activities.