Solid phase synthesis and ant parasitic activity of a library of peptidyl metronidazoles
Joint Authors
al-Gharabli, Samir
al-Rifai, Nafisah
Saadah, Haytham A.
Muslih, Ibrahim M.
Mubarak, Muhammad S.
Source
Issue
Vol. 5, Issue 2 (30 Jun. 2010), pp.139-147, 9 p.
Publisher
Yarmouk University Deanship of Research and Graduate Studies
Publication Date
2010-06-30
Country of Publication
Jordan
No. of Pages
9
Main Subjects
Topics
Abstract EN
A number of peptidyl metronidazole derivatives were synthesized in 99% yield through solid phase peptide synthesis.
The newly prepared compounds were tested against Endameba histolytic and Giardia intestinal is and was found to be much less active than metronidazole against the aforementioned parasites; apparently the introduction of the peptide moiety on the metronidazole nucleus has an adverse effect on their ant parasitic activities.
Nevertheless, grafting metronidazole with amino acids opens the window for parallel screening and combinatorial approaches.
American Psychological Association (APA)
al-Gharabli, Samir& al-Rifai, Nafisah& Saadah, Haytham A.& Muslih, Ibrahim M.& Mubarak, Muhammad S.. 2010. Solid phase synthesis and ant parasitic activity of a library of peptidyl metronidazoles. Jordan Journal of Chemistry،Vol. 5, no. 2, pp.139-147.
https://search.emarefa.net/detail/BIM-266298
Modern Language Association (MLA)
al-Gharabli, Samir…[et al.]. Solid phase synthesis and ant parasitic activity of a library of peptidyl metronidazoles. Jordan Journal of Chemistry Vol. 5, no. 2 (Jun. 2010), pp.139-147.
https://search.emarefa.net/detail/BIM-266298
American Medical Association (AMA)
al-Gharabli, Samir& al-Rifai, Nafisah& Saadah, Haytham A.& Muslih, Ibrahim M.& Mubarak, Muhammad S.. Solid phase synthesis and ant parasitic activity of a library of peptidyl metronidazoles. Jordan Journal of Chemistry. 2010. Vol. 5, no. 2, pp.139-147.
https://search.emarefa.net/detail/BIM-266298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 146-147
Record ID
BIM-266298