Asymmetric addition of diethyl zinc to benzaldehyde catalyzed by chiral diamine ligand and ti-diamine modified complex derived from d-mannitol

Abstract EN

Modified procedure for preparation of chiral: 3, 4-Diazido-1, 2:5, 6-di-O-isopropylidene-Dmannitol from the corresponding bismesylate and new chiral ligand: 3, 4-diamino-1, 2:5, 6-Oisopropylidene- D-mannitol was described.

The application of both diamine and Ti-diamine complex as catalysts in enantioselective addition of diethyl zinc to parochial Benz aldehyde was described.

High enantioselectivity up to 93% e.e.

was achieved.

The standard analytical measurements including optical activity of the Diaz ide, dopamine and the determination of optical purity of the resulting alcohol were reported.