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Use of iron (III) chloride for the sensitive and selective assay of etamsylate in pharmaceuticals
Joint Authors
Vinay, Kanakapura Basavaiah
Revanasiddappa, Hosakere Doddarevanna
Devi, Okram Zenita
Basavaiah, Kanakapura
Source
Issue
Vol. 5, Issue 3 (30 Sep. 2010), pp.291-305, 15 p.
Publisher
Yarmouk University Deanship of Research and Graduate Studies
Publication Date
2010-09-30
Country of Publication
Jordan
No. of Pages
15
Main Subjects
Topics
Abstract EN
Two simple and selective spectrophotometric methods have been proposed for the assay of etamsylate (ETM) in bulk and dosage forms.
The first method (method A) is based on the reaction of ETM with ferric chloride in dimethylformamide (DMF) medium to form a colored species with a λmax at 655 nm.
The second method (method B) is based on the oxidative coupling reaction involving ETM, 3-methyl-2- benzothiazolinone hydrazine (MBTH) and ferric chloride in the presence of sodium acetate which yielded a bright pink colored chromogenic with λmax.at 520 nm.
The amount of chromogenic formed corresponds to the amount of ETM and the measured absorbance is found to increase linearly with the concentration of ETM, which is corroborated by the correlation coefficient of 0.999 in both the methods.
Under optimum conditions, Beer’s law is obeyed over the ranges 4.0-140 and 1.5-30 μ gmL-1 for method A and method B respectively.
The calculated molar absorptivity values are1.68 × 103 and 7.83 × 103 L moL-1 cm-1 for method A and method B, respectively and the corresponding sand ell sensitivities are 0.156 and 0.033 μ g cm-2.
The proposed methods were applied to the analysis of tablet forms of ETM and the results tallied well with the label claim.
No interference was observed from concomitant substances normally added to tablets.
The results were statistically compared with those of a literature method by applying the Student’s t-test and F-test.
The accuracy and validity of the methods were further ascertained by performing recovery studies via spike method.
American Psychological Association (APA)
Vinay, Kanakapura Basavaiah& Revanasiddappa, Hosakere Doddarevanna& Devi, Okram Zenita& Basavaiah, Kanakapura. 2010. Use of iron (III) chloride for the sensitive and selective assay of etamsylate in pharmaceuticals. Jordan Journal of Chemistry،Vol. 5, no. 3, pp.291-305.
https://search.emarefa.net/detail/BIM-266333
Modern Language Association (MLA)
Devi, Okram Zenita…[et al.]. Use of iron (III) chloride for the sensitive and selective assay of etamsylate in pharmaceuticals. Jordan Journal of Chemistry Vol. 5, no. 3 (Sep. 2010), pp.291-305.
https://search.emarefa.net/detail/BIM-266333
American Medical Association (AMA)
Vinay, Kanakapura Basavaiah& Revanasiddappa, Hosakere Doddarevanna& Devi, Okram Zenita& Basavaiah, Kanakapura. Use of iron (III) chloride for the sensitive and selective assay of etamsylate in pharmaceuticals. Jordan Journal of Chemistry. 2010. Vol. 5, no. 3, pp.291-305.
https://search.emarefa.net/detail/BIM-266333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 304-305
Record ID
BIM-266333